Determination of the precise location and degree of condition of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment. Given the complimentary contrast mechanisms of Photoacoustic microscopy (PAM) and Optical coherence tomography (OCT), the combination of PAM and OCT imaging could potentially provide much sensitive and specific detection of CNV. In this paper, we validated the opportunity to evaluate the information of laser-induced CNV and presented the in vivo time-serial evaluation of the CNV by simultaneously using PAM and OCT techniques. In vivo PAM and OCT examination was performed after laser photocoagulation applied to the rat fundus at days 1, 3, 5, 7, 14. Time-serial results showed that CNV in rats increased to its maximum at day 7 and decreased at day 14. Evolution of CNV information was given in PAM images with a high contrast and details of high axial resolution OCT images were simultaneously given to show the hyperreflective reaction progress.
A theoretical simulation of multi-beam coupling in LiNbO3:Fe:Mn crystals is given based on jointly solving the
two-center material equations and the coupled-wave equations. Within a single crystal, multiple signals are amplified
through coupling process from the pump light. The coupling gain of each signal results from coupling both between the
pump and the signal and between different signals. The gain of each signal receives is dependent on the intensity of the
signal light. And a competition is found between the various signals.
A dynamic three-dimensional (3D) display method based on Liquid Crystal on Silicon (LCoS) spatial light modulator is
introduced in this paper. Sixty viewing-angles are set at regular intervals of six degrees along a complete circle in the
horizontal plane, and phase holograms of three-dimensional virtual object are calculated under these viewing-angles by
use of computational tomographic method as well as spatial coordinate transformation. Multi- kinoforms are calculated
for each angle by adding proper pseudorandom phase in each object plane, which can avoid losing spectrum information
and be able to reduce the speckle noise of reconstructed image. These kinoforms are written to a 3D electro-holographic
display system based on LC-R2500 spatial light modulator (SLM) by a proper loading sequence. A 650 nm diode laser
with power of 150 mW is used in the system. A transparent screen is taken as a display media, which could show
three-dimensional images reconstructed from holograms loaded on LC-R2500. A pair of Fresnel lenses is used to
improve the viewing effect and three-dimensional images floating in space can be viewed by multiple observers.
Stitching technology is used to enlarge the tested area in interference and fringe projection system. By using this method
we can test the profile of object which is larger than testing aperture. In the traditional digital holographic technique,
only small objects can be recorded and reconstructed. In this study, a holographic phase stitching technique is proposed
to solve this problem. Differ from the interference and fringe projection stitching, holographic phase stitching has its
characteristic in the holographic diffraction process. In this paper, taking plane image measurement as an example, the
theory of holographic phase stitching is presented. Stitching errors in the holographic phase stitching are deeply analyzed
and relevant 2×2 stitching simulation is performed using a phase grating.
Based on the principle of holographic imaging, the electroholographic display of digital holograms is performed with a
liquid crystal device, LC-R 2500. The size and the position of the reconstruction image are effectively described and
numerically analyzed, and the 3-D display is demonstrated by reconstructing a synthesized hologram calculated with
volume slice approach. Theoretical results confirm and predict experimental results, and further research to optimize the
3-D reconstruction is suggested.
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