We present the integration of a miRNA sensing probe technology with a bimetallic nanostar-based surfaced-enhanced Raman scattering (SERS) substrate for disease detection. Circulating microRNAs (miRNA) are being investigated as promising diagnostic biomarkers for many cancers, including colorectal cancer (CRC). The inverse molecular sentinel technology was used for amplification-free multiplexed detection of miRNA targets using SERS. The integration of these technologies lays the foundation for point of care device design, capable of miRNA profiling without the need for traditional sample preparation of nucleotide amplification techniques.
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