The diagnosis and treatment of dermatological diseases has always been valued, and the laser therapy is one of the main methods for the treatment of skin diseases. Optical Coherence Tomography (OCT) is a non-invasive, label-free, high-resolution and high-speed imaging technique, which is very suitable as a diagnostic tool in dermatology. In this study, we developed an Ultrahigh-Resolution OCT system (UHR-OCT), with below 2 μm in both axial and lateral resolution in tissue. The system is implemented to observe skin microstructure and layering, and to investigate postoperative follow-up of laser therapy. The results show that the developed UHR-OCT system can clearly distinguish the microstructure and layering of the skin, meaning that the system is well-suitable for skin diagnosis. In addition, we also investigated the photodamage such as LIOB in the tracking of laser treatment, which confirmed the value of UHR-OCT system in dermatology and laser treatment.
In this study, a Swept-Source Optical Coherence Tomography (SS-OCT) system and a Raman fiber laser with high laser output are used to investigate the photothermal effect on biological tissue. An optical focuser is connected to the Raman fiber laser to focus the laser power on the specific area of the tissue. To simultaneously observe the induced photothermal effect, a dynamic algorithm is used in the process to produce dynamic image of the tissue from time-series OCT images. The results show that with dynamic images, we can identify the extent and area of laser ablation with time. Moreover, after merging the dynamic image and the original OCT image, we can indicate the ablated area in the tissue apart from the surrounding area without ablation.
In this study, a portable and ultrahigh-resolution OCT (UHR-OCT) system is developed, and the axial and transverse resolutions are approximately 2 and 5 m, respectively. Although picosecond lasers are widely used for clinical treatment, it is difficult to predict and observe the treatment outcome. The developed UHR-OCT system is implemented to observe the photodamage induced by the picosecond laser and the laser-induced optical breakdown (LIOB) can be observed. Furthermore, the recovery process is studied and compared by UHR-OCT. The results indicate that the UHR-OCT system can clearly identify the skin structures, and the induced photodamage can be quantitatively evaluated.
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