Mr. Yunfei Yu Profile

Yunfei Yu

at Fujian Normal Univ.

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Proceedings Article | 20 November 2019 Paper

Detection of singlet oxygen luminescence in skin phantom based on optical fiber detection

Ying Hu, Lisheng Lin, Lina Liu, Yunfei Yu, Xianglian Liao, Ying Gu, Buhong Li

Proceedings Volume 11190, 111902X (2019) https://doi.org/10.1117/12.2537692

KEYWORDS: Luminescence, Oxygen, Scattering, Optical fibers, Skin, Absorption, Photodynamic therapy, Tissue optics, Light scattering, Sensors

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Singlet oxygen (¹O₂) is widely considered as the major cytotoxic species generated during Type-II photochemical reaction of photodynamic therapy (PDT), and its production is crucial for the treatment outcome of PDT. However, it is still a challenging task for direct detection of ¹O₂ by using an optical system as its extremely weak luminescence at 1270 nm. In previous study, a high-sensitivity optical fiber detection system has been developed to measure the time-resolved ¹O₂ luminescence spectra. In this study, an optical phantom of skin tissue has been built to simulate the skin optical properties for research in photodynamic therapy (PDT). The phantom consists of an absorber (ink) and a scatterer (Intralipid) and phosphate buffer saline (PBS). Rose Bengal (RB) was utilized as the model photosensitizer to generate ¹O₂. The time-resolved ¹O₂ luminescence spectroscopy were measured by using a ¹O₂ luminescence detection system with a fiber prober in tissue phantom. Furthermore, the effect of absorption coefficient (μ_a) and scattering coefficient (μ_s) on the photosensitizer triple state lifetime (τ_T) and ¹O₂ luminescence lifetime (τ_D) was investigated as well. The results indicated that the integrated intensity of ¹O₂ luminescence decrease with the increase of μ_a and μ_s. μ_a has no significant effect on τ_T and τ_D. τ_T increase with the increase of μ_s, and it finally stabilized around 1.6 μs. Meanwhile, τ_D decrease firstly and then increase slowly, and it finally stabilized around 14 μs. This result indicates that this system for ¹O₂ luminescence have a potential for clinical applications in PDT dosimetry.

Proceedings Article | 23 October 2018 Paper

Impacts of vascular diameter and depth on singlet oxygen luminescence imaging in tissue simulating phantom

Xianglian Liao, Yi Shen, Yunfei Yu, Huiyun Lin, Lisheng Lin, Ying Gu, Buhong Li

Proceedings Volume 10820, 108203I (2018) https://doi.org/10.1117/12.2502717

KEYWORDS: Luminescence, Capillaries, Tissues, Photodynamic therapy, Blood vessels, Imaging systems

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Singlet oxygen (¹O₂) is the primary cytotoxic production in type-II photodynamic therapy (PDT). The correlation between ¹O₂ generation and PDT efficacy during treatment has received considerable attention. The direct detection of ¹O₂ luminescence is the gold standard for ¹O₂ identification. However, the intensity of ¹O₂ luminescence could be influenced by tissue optical properties, location and morphology of lesion, especially for vascular targeting PDT. In this study, the impacts of vascular diameter and depth on ¹O₂ luminescence imaging have been investigated in tissue simulating phantom. A near-IR sensitive InGaAs camera with adaptive optics and CW laser 532 nm were used for fast imaging of ¹O₂ luminescence. Rose Bengal (RB) was used as photosensitizer to generate ¹O₂ during photosensitization. Intralipid was diluted with different concentrations in order to establish the scattering properties of tissues. The capillary tubes, containing solution of RB, with varied diameters from 0.1 to 0.9 mm were used to simulate the vascular with the depth varied from 0 to 5 mm in phantom. The preliminary results indicate that the profile range ratio of ¹O₂ luminescence images are negatively correlated to the diameter of capillary tube, and the attenuation of intensity of ¹O₂ luminescence is non-linear with the increase of depth.

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