Dr. Zhixing Xie Profile

Dr. Zhixing Xie

Research Fellow, Radiology at Univ of Michigan Medical School

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Author

Publications (16)

Proceedings Article | 15 March 2016 Paper

Label-free imaging of gold nanoparticles in single live cells by photoacoustic microscopy

Chao Tian, Wei Qian, Xia Shao, Zhixing Xie, Xu Cheng, Shengchun Liu, Qian Cheng, Bing Liu, Xueding Wang

Proceedings Volume 9708, 970857 (2016) https://doi.org/10.1117/12.2213744

KEYWORDS: Gold, Nanoparticles, Photoacoustic microscopy, Confocal microscopy, Microscopy, Live cell imaging, Image resolution, Photoacoustic spectroscopy, Prostate, Luminescence, Visualization, Cancer, Transmission electron microscopy, Nanomedicine

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Proceedings Article | 11 March 2015 Paper

Imaging and sensing based on dual-pulse nonlinear photoacoustic contrast: a preliminary study on fatty liver

Chao Tian, Zhixing Xie, Mario Fabiilli, Xueding Wang

Proceedings Volume 9323, 93231E (2015) https://doi.org/10.1117/12.2078453

KEYWORDS: Liver, Photoacoustic spectroscopy, Tissues, Blood, Tissue optics, Absorption, Pulsed laser operation, Laser tissue interaction, Transducers, Signal detection

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Proceedings Article | 4 March 2014 Paper

3D high resolution photoacoustic imaging based on pure optical photoacoustic microscopy with microring resonator

Zhixing Xie, Chao Tian, Sung-Liang Chen, Tao Ling, Cheng Zhang, L. Jay Guo, Paul Carson, Xueding Wang

Proceedings Volume 8943, 894314 (2014) https://doi.org/10.1117/12.2041010

KEYWORDS: Microrings, Resonators, Tissue optics, Image resolution, Photoacoustic microscopy, Optical microscopy, Sensors, 3D image processing, Photoacoustic spectroscopy, Signal detection

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Proceedings Article | 3 March 2014 Paper

Photoacoustic microscopy for quantitative evaluation of angiogenesis inhibitor

Sung-Liang Chen, Joseph Burnett, Duxin Sun, Zhixing Xie, Xueding Wang

Proceedings Volume 8943, 89433S (2014) https://doi.org/10.1117/12.2038054

KEYWORDS: Content addressable memory, 3D image processing, Photoacoustic microscopy, Capillaries, Cancer, Tissues, Functional imaging, Oncology, Binary data, Optical microscopy

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Proceedings Article | 3 March 2014 Paper

Prototype study on a miniaturized dual-modality imaging system for photoacoustic microscopy and confocal fluorescence microscopy

Sung-Liang Chen, Zhixing Xie, L. Jay Guo, Xueding Wang

Proceedings Volume 8943, 89430B (2014) https://doi.org/10.1117/12.2038050

KEYWORDS: Imaging systems, Confocal microscopy, Prototyping, Mirrors, Endoscopy, Bladder, Luminescence, Microelectromechanical systems, Tissues, Signal detection

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Proceedings Article | 4 March 2013 Paper

Viewing individual cells and ambient microvasculature using two molecular contrasts

Zhixing Xie, Sung-Liang Chen, Mario Fabiilli, J. Brian Fowlkes, K. Kirk Shung, Qifa Zhou, Xunbin Wei, Paul Carson, Xueding Wang

Proceedings Volume 8581, 85813G (2013) https://doi.org/10.1117/12.2004666

KEYWORDS: Bladder, Luminescence, Imaging systems, Confocal microscopy, Signal detection, Photoacoustic spectroscopy, In vivo imaging, Absorption, Tumors, Microscopy

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Proceedings Article | 4 March 2013 Paper

Combined photoacoustic and ultrasound imaging of human breast in vivo in the mammographic geometry

Zhixing Xie, Won-Mean Lee, Fong Ming Hooi, J. Brian Fowlkes, Renee Pinsky, Dean Mueller, Xueding Wang, Paul Carson

Proceedings Volume 8581, 85813D (2013) https://doi.org/10.1117/12.2004599

KEYWORDS: Breast, Ultrasonography, Imaging systems, Blood, 3D image processing, Tissues, Photoacoustic spectroscopy, 3D acquisition, Image compression, Mammography

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Proceedings Article | 4 March 2013 Paper

High resolution photoacoustic imaging of microvasculature in normal and cancerous bladders

Zhixing Xie, William Roberts, Paul Carson, Xiaojun Liu, Chao Tao, Xueding Wang

Proceedings Volume 8581, 85810J (2013) https://doi.org/10.1117/12.2004482

KEYWORDS: Bladder, Tissues, Bladder cancer, Tumors, Cancer, Tissue optics, Image resolution, Photoacoustic imaging, 3D image processing, Signal detection

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Proceedings Article | 4 March 2013 Paper

All-optical photoacoustic microscopy using a MEMS scanning mirror

Sung-Liang Chen, Zhixing Xie, Tao Ling, Xunbin Wei, L. Jay Guo, Xueding Wang

Proceedings Volume 8581, 85812G (2013) https://doi.org/10.1117/12.2002684

KEYWORDS: Microrings, Microelectromechanical systems, Mirrors, Bladder, Photoacoustic spectroscopy, Imaging systems, Bladder cancer, Sensors, Photoacoustic microscopy, Resonators

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Proceedings Article | 23 February 2012 Paper

3D high resolution pure optical photoacoustic microscopy

Zhixing Xie, Sung-Liang Chen, Tao Ling, L. Jay Guo, Paul Carson, Xueding Wang

Proceedings Volume 8223, 82230W (2012) https://doi.org/10.1117/12.906767

KEYWORDS: Microrings, Resonators, Tissue optics, Image resolution, Acoustics, Transducers, Sensors, Bladder, Photoacoustic spectroscopy, Waveguides

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The concept of pure optical photoacoustic microscopy(POPAM) was proposed based on optical rastering of a focused excitation beam and optically sensing the photoacoustic signal using a microring resonator fabricated by a nanoimprinting technique. After some refinedment of in the resonator structure and mold fabrication, an ultrahigh Q factor of 3.0×105 was achieved which provided high sensitivity with a noise equivalent detectable pressure(NEDP) value of 29Pa. This NEDP is much lower than the hundreds of Pascals achieved with existing optical resonant structures such as etalons, fiber gratings and dielectric multilayer interference filters available for acoustic measurement. The featured high sensitivity allowed the microring resonator to detect the weak photoacoustic signals from micro- or submicroscale objects. The inherent superbroad bandwidth of the optical microring resonator combined with an optically focused scanning beam provided POPAM of high resolution in the axial as well as both lateral directions while the axial resolution of conventional photoacoustic microscopy (PAM) suffers from the limited bandwidth of PZT detectors. Furthermore, the broadband microring resonator showed similar sensitivity to that of our most sensitive PZT detector. The current POPAM system provides a lateral resolution of 5μm and an axial resolution of 8μm, comparable to that achieved by optical microscopy while presenting the unique contrast of optical absorption and functional information complementing other optical modalities. The 3D structure of microvasculature, including capillary networks, and even individual red blood cells have been discerned successfully in the proof-of-concept experiments on mouse bladders ex vivo and mouse ears in vivo. The potential of approximately GHz bandwidth of the microring resonator also might allow much higher resolution than shown here in microscopy of optical absorption and acoustic propagation properties at depths in unfrozen tissue specimens or thicker tissue sections not now imageable with current optical or acoustic microscopes of comparable resolution.

Proceedings Article | 23 February 2012 Paper

Photoacoustic correlation spectroscopy for in vivo blood flow speed measurement

Sung-Liang Chen, Zhixing Xie, Paul Carson, Xueding Wang, L. Jay Guo

Proceedings Volume 8223, 82230O (2012) https://doi.org/10.1117/12.908442

KEYWORDS: Photoacoustic spectroscopy, Capillaries, Picture Archiving and Communication System, Blood, In vivo imaging, Blood circulation, Spectroscopy, Particles, Photoacoustic imaging, Imaging systems

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Proceedings Article | 11 April 2011 Paper

Photoacoustic imaging for deep targets in the breast using a multichannel 2D array transducer

Zhixing Xie, Xueding Wang, Richard Morris, Frederic Padilla, Gerald Lecarpentier, Paul Carson

Proceedings Volume 7899, 789907 (2011) https://doi.org/10.1117/12.875138

KEYWORDS: Breast, Imaging systems, Interference (communication), Tissues, Photoacoustic imaging, Transducers, 3D image processing, Photoacoustic spectroscopy, Ferroelectric polymers, Blood

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SPIE Journal Paper | 1 March 2010 Open Access

In vitro testing of a protease-sensitive contrast agent for optoacoustic imaging

Anthony Green, James Norris, Jing Wang, Zhixing Xie, Hao Zhang, Patrick La Rivière

JBO, Vol. 15, Issue 02, 021315, (March 2010) https://doi.org/10.1117/12.10.1117/1.3365935

KEYWORDS: Absorption, Molecules, In vitro testing, Molecular aggregates, Mass attenuation coefficient, In vivo imaging, Luminescence, Tissue optics, Magnesium, Tumors

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Proceedings Article | 23 February 2010 Paper

In vitro testing of a protease-sensitive contrast agent for optoacoustic imaging

Anthony Green, James Norris, Jing Wang, Zhixing Xie, Hao Zhang, Patrick La Riviere

Proceedings Volume 7564, 75641T (2010) https://doi.org/10.1117/12.842480

KEYWORDS: Absorption, Molecules, Mass attenuation coefficient, Molecular aggregates, Signal attenuation, In vivo imaging, Tumors, In vitro testing, Dye lasers, Near infrared

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Proceedings Article | 25 February 2009 Paper

Laser-scanning optical-resolution photoacoustic microscopy

Hao Zhang, Zhixing Xie, Shuliang Jiao, Carmen Puliafito

Proceedings Volume 7177, 71770L (2009) https://doi.org/10.1117/12.815396

KEYWORDS: Ultrasonics, Data acquisition, Transducers, Tissue optics, Laser optics, Integrated optics, Spatial resolution, Pulsed laser operation, Sensors, Photoacoustic microscopy

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Proceedings Article | 24 February 2009 Paper

Monte Carlo simulation of light transport in dark-field confocal photoacoustic microscopy

Zhixing Xie, Lihong Wang, Hao Zhang

Proceedings Volume 7177, 717717 (2009) https://doi.org/10.1117/12.810254

KEYWORDS: Tissue optics, Confocal microscopy, Beam shaping, Geometrical optics, Optical simulations, Monte Carlo methods, Convolution, Acoustics, Image quality, Signal to noise ratio

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Showing 5 of 16 publications

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