Feasibility of Raman spectroscopy to characterize and detect oropharyngeal cancer

Sanidhya D. Tripathi; Sean T. Fitzgerald; Giju Thomas; Justin R. Shinn; Carey B. Wood; Young J. Kim; Anita Mahadevan-Jansen

doi:10.1117/12.2609197

7 March 2022 Feasibility of Raman spectroscopy to characterize and detect oropharyngeal cancer

Sanidhya D. Tripathi, Sean T. Fitzgerald, Giju Thomas, Justin R. Shinn, Carey B. Wood, Young J. Kim, Anita Mahadevan-Jansen

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Proceedings Volume PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; PC119570G (2022) https://doi.org/10.1117/12.2609197
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Oropharyngeal squamous cell carcinoma (OPSCC) which refers to the cancer of the back of the throat, including the base of tongue and tonsils, has rapidly increased the past several decades and if undiagnosed, the tumors metastasize leading to many complications and decreased survival. In this study, Raman spectroscopy (RS) in combination with data classification algorithms was used to examine tonsil specimens (normal, benign, and malignant) to determine if RS could serve as a viable tool for real-time sensitive detection of OPSCC and ultimately other HPV-linked cancers.

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Sanidhya D. Tripathi, Sean T. Fitzgerald, Giju Thomas, Justin R. Shinn, Carey B. Wood, Young J. Kim, and Anita Mahadevan-Jansen "Feasibility of Raman spectroscopy to characterize and detect oropharyngeal cancer", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570G (7 March 2022); https://doi.org/10.1117/12.2609197

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KEYWORDS

Cancer

Raman spectroscopy

Tissues

Light scattering

Machine learning

Remote sensing

Tumors

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