Continuous-wave spectroscopic singlet oxygen sensor for photodynamic therapy dosimetry in a murine model of actinic keratosis

Sanjay Anand; Tiffany Yu; Cheng-En Cheng; Steven J. Davis; Youbo Zhao; Edward V. Maytin

doi:10.1117/12.2650207

17 March 2023 Continuous-wave spectroscopic singlet oxygen sensor for photodynamic therapy dosimetry in a murine model of actinic keratosis

Sanjay Anand, Tiffany Yu, Cheng-En Cheng, Steven J. Davis, Youbo Zhao, Edward V. Maytin

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Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235903 (2023) https://doi.org/10.1117/12.2650207
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We demonstrate a high throughput spectrometer system for real-time measurement of singlet oxygen (1O2) luminescence during photodynamic therapy (PDT). High signal-to-noise spectroscopic data allows for more accurate determination of photosensitizer luminescence baseline via spectral fitting and thus the extraction of 1O2 phosphorescence signal based solely on spectroscopic decomposition, without the need for temporal gating. This enables direct 1O2 measurement in continuous-wave mode, enabling potential clinical use of the technology as a PDT dosimeter. We present results from both in-vitro phantom and in-vivo murine actinic keratosis lesion clearance studies that investigated the correlation of treatment effect with 1O2 measurements during PDT.

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Sanjay Anand, Tiffany Yu, Cheng-En Cheng, Steven J. Davis, Youbo Zhao, and Edward V. Maytin "Continuous-wave spectroscopic singlet oxygen sensor for photodynamic therapy dosimetry in a murine model of actinic keratosis", Proc. SPIE PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, PC1235903 (17 March 2023); https://doi.org/10.1117/12.2650207

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KEYWORDS

Photodynamic therapy

Spectroscopy

Oxygen

Continuous wave operation

Sensors

Tumor growth modeling

Luminescence

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