Visually evoked blood flow change in the trilaminar retinal vasculature using OCT capillary velocimetry

Bingyao Tan; Ouyang Qingling; Veluchamy Barathi; Leopold Schmetterer

doi:10.1117/12.2652450

9 March 2023 Visually evoked blood flow change in the trilaminar retinal vasculature using OCT capillary velocimetry

Bingyao Tan, Ouyang Qingling, Veluchamy Barathi, Leopold Schmetterer

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670F (2023) https://doi.org/10.1117/12.2652450
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Here, we demonstrate the visual evoked blood flow change in trilaminar retinal vasculature in rodents using OCT capillary velocimetry. A custom-built spectral-domain optical coherence tomography operates on 800 nm region performed all the imaging. In-vivo measurements were conducted on dark-adapted Brown Norway rats. The retinal blood flow velocity was calculated using a modified dynamic light scattering (DLS) – OCT method. As a result, the blood flow velocity in arterioles, venules, and capillaries in the retinal vasculature can be resolved. Flicker stimulation triggered heterogeneous responses – reduced flow velocity in large vessels vs. increased flow velocity in capillaries.

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Citation Download Citation

Bingyao Tan, Ouyang Qingling, Veluchamy Barathi, and Leopold Schmetterer "Visually evoked blood flow change in the trilaminar retinal vasculature using OCT capillary velocimetry", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670F (9 March 2023); https://doi.org/10.1117/12.2652450

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KEYWORDS

Blood circulation

Capillaries

Optical coherence tomography

Visualization

Velocimetry

Alzheimer's disease

Cornea

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