Characterizing the micro-mechanical entropy in molecular subtypes of breast cancer by laser speckle rheological microscopy (Conference Presentation)

Zeinab Hajjarian Kashany; Seemantini Nadkarni

doi:10.1117/12.2651040

15 March 2023 Characterizing the micro-mechanical entropy in molecular subtypes of breast cancer by laser speckle rheological microscopy (Conference Presentation)

Zeinab Hajjarian Kashany, Seemantini Nadkarni

Author Affiliations +

Proceedings Volume PC12381, Optical Elastography and Tissue Biomechanics X; PC123810G (2023) https://doi.org/10.1117/12.2651040
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Altered tissue stiffness has raised as both the cause and the consequence of breast tumorigenesis. Imaging the heterogeneous mechanical properties of tissue microenvironment provides crucial insights into micro-mechanical attributes of aggressive behavior. Here, we exploit laser Speckle rHEologicAl micRoscopy (SHEAR), to map the shear viscoelastic modulus, G*(x,y,ω), of excised breast specimens. Results demonstrate that micromechanical entropy of the tumor microenvironment is significantly reduced in aggressive triple-negative tumors compared to other molecular subtypes. These findings highlight the prognostic yield of tumor micromechanical entropy, measured by SHEAR.

Conference Presentation

Citation Download Citation

Zeinab Hajjarian Kashany and Seemantini Nadkarni "Characterizing the micro-mechanical entropy in molecular subtypes of breast cancer by laser speckle rheological microscopy (Conference Presentation)", Proc. SPIE PC12381, Optical Elastography and Tissue Biomechanics X, PC123810G (15 March 2023); https://doi.org/10.1117/12.2651040

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