An investigation is made of the possibility of obtaining reliable measurements of tissue density from digital chest radiographs. This involves assessment of the repeatability and uniformity of x-ray exposure using microdensitometry of conventional film and estimation of scattered radiation. The range of variation of film density spatially and over time was found to be within ±0.03 optical density units (O.D.). Scatter fraction measurements using partial absorbers gave results within, on average, 6% of the conventional measurement and was found to be approximately linearly related to mass/unit area. By correcting for film response and scatter, measurement of a variety of densities of foam rubber was found to correlate well with true density, with an average error of 5%. The estimation of regional lung ventilation from inspiration/expiration radiographs is investigated, using spatial warping techniques to facilitate the identification of corresponding areas of the two radiographs.
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