A simple optical fibre probe for differentiation between healthy and tumorous tissue

Erik P. Schartner; Matthew R. Henderson; Malcolm Purdey; Tanya M. Monro; P. Grantley Gill; David F. Callen

doi:10.1117/12.2248685

24 November 2016 A simple optical fibre probe for differentiation between healthy and tumorous tissue

Erik P. Schartner, Matthew R. Henderson, Malcolm Purdey, Tanya M. Monro, P. Grantley Gill, David F. Callen

Proceedings Volume 10013, SPIE BioPhotonics Australasia; 100133M (2016) https://doi.org/10.1117/12.2248685
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

Incomplete removal of malignant tumours continues to be a significant issue in cancer surgery. It increases the risk of local recurrence and impaired survival, and results in the need for additional surgery with associated attendant costs and morbidity. While pathological methods exist to determine tissue type during surgery, these methods can compromise post-operative pathology, have a lag of minutes to hours before the surgeon receives the results of the tissue analysis and are restricted to excised tissue.

In this work we report the development of an optical fibre probe which could find use as an aid for margin detection during surgery. A fluorophore doped polymer coating is deposited on the tip of an optical fibre, which can then be used to record the pH by monitoring the emission spectra from the embedded indicator. The pH values of unknown tissue are measured and compared to healthy tissue, allowing for discrimination between healthy and cancerous tissue.

The probe developed here shows strong potential for use during surgery, as the probe design can be readily adapted to a low-cost portable configuration which could find use in the operating theatre. Use of this probe in surgery either on excised or in-vivo tissue has the potential to improve success rates for complete removal of cancers.

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Erik P. Schartner, Matthew R. Henderson, Malcolm Purdey, Tanya M. Monro, P. Grantley Gill, and David F. Callen "A simple optical fibre probe for differentiation between healthy and tumorous tissue", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100133M (24 November 2016); https://doi.org/10.1117/12.2248685

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KEYWORDS

Tissues

Surgery

Tissue optics

Optical fibers

Cancer

Luminescence

Pathology

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