Preliminary experiments on pharmacokinetic diffuse fluorescence tomography of CT-scanning mode

Yanqi Zhang; Xin Wang; Guoyan Yin; Jiao Li; Zhongxing Zhou; Huijuan Zhao; Feng Gao; Limin Zhang

doi:10.1117/12.2245951

31 October 2016 Preliminary experiments on pharmacokinetic diffuse fluorescence tomography of CT-scanning mode

Yanqi Zhang, Xin Wang, Guoyan Yin, Jiao Li, Zhongxing Zhou, Huijuan Zhao, Feng Gao, Limin Zhang

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100242Y (2016) https://doi.org/10.1117/12.2245951
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

In vivo tomographic imaging of the fluorescence pharmacokinetic parameters in tissues can provide additional specific and quantitative physiological and pathological information to that of fluorescence concentration. This modality normally requires a highly-sensitive diffuse fluorescence tomography (DFT) working in dynamic way to finally extract the pharmacokinetic parameters from the measured pharmacokinetics-associated temporally-varying boundary intensity. This paper is devoted to preliminary experimental validation of our proposed direct reconstruction scheme of instantaneous sampling based pharmacokinetic-DFT: A highly-sensitive DFT system of CT-scanning mode working with parallel four photomultiplier-tube photon-counting channels is developed to generate an instantaneous sampling dataset; A direct reconstruction scheme then extracts images of the pharmacokinetic parameters using the adaptive-EKF strategy. We design a dynamic phantom that can simulate the agent metabolism in living tissue. The results of the dynamic phantom experiments verify the validity of the experiment system and reconstruction algorithms, and demonstrate that system provides good resolution, high sensitivity and quantitativeness at different pump speed.

Citation Download Citation

Yanqi Zhang, Xin Wang, Guoyan Yin, Jiao Li, Zhongxing Zhou, Huijuan Zhao, Feng Gao, and Limin Zhang "Preliminary experiments on pharmacokinetic diffuse fluorescence tomography of CT-scanning mode", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242Y (31 October 2016); https://doi.org/10.1117/12.2245951

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