Synthesis and application of the reduction-sensitive drug delivery system based on water-soluble ZnInAgS quantum dots

Dawei Deng; Rong Zhang; Lingzhi Qu; Fangjian Bao; Jie Wang; Tao Deng

doi:10.1117/12.2246760

31 October 2016 Synthesis and application of the reduction-sensitive drug delivery system based on water-soluble ZnInAgS quantum dots

Dawei Deng, Rong Zhang, Lingzhi Qu, Fangjian Bao, Jie Wang, Tao Deng

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100244P (2016) https://doi.org/10.1117/12.2246760
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

High-quality water-soluble quantum dots had been synthesized following the one-step method. Furtherly, the impact factors on the optical properties of quantum dots, which were the feed ratio of S/In and the reflux time, had been concerned emphatically. By changing the reaction parameters, we made the fluorescence emission of ZnInAgS quantum dot tunable from green to orange, and the maximum fluorescence quantum efficiency was up to 30%. Then we modified bovine serum albumin (BSA) on the surface of ZnInAgS quantum dot, which was conjugated with BSA-QDs through the linker of 3'3-dimercapto-diacetate DOX. Finally, the reduction-sensitive drug delivery system based on ZnInAgS quantum dots (QBSSD) was successfully constructed. The resultant QBSSD complex were observed to be significantly stable in aqueous solution. In addition, owing to their cellular reduction responsiveness at the cleavable disulfide linker, the QBSSD complex were able to release DOX rapidly. In vitro drug release and cell level release experiments proved that our QBSSD complexes could make a quick drug release in the environment with GSH. The efficacy experiments showed that our QBSSD complexes exhibited a strong killing effect to cancer cells, and low toxic to normal cells. All the results indicated that the reduction-sensitive drug delivery system was a promising model of administration.

Citation Download Citation

Dawei Deng, Rong Zhang, Lingzhi Qu, Fangjian Bao, Jie Wang, and Tao Deng "Synthesis and application of the reduction-sensitive drug delivery system based on water-soluble ZnInAgS quantum dots", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100244P (31 October 2016); https://doi.org/10.1117/12.2246760

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KEYWORDS

Quantum dots

Luminescence

Absorption

Cancer

FT-IR spectroscopy

Biomedical optics

Magnesium

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