Presentation + Paper
21 February 2017 A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT
Timothy C. Zhu, Michele M. Kim, Yi-Hong Ong, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Carmen Rodriguez, Keith A. Cengel
Author Affiliations +
Abstract
Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. A dualcorrection algorithm is used to improve the agreement between calculations and in-situ measurements. A comprehensive analysis of the distribution of light fluence during PDT is presented in both phantom conditions and in clinical cases.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Timothy C. Zhu, Michele M. Kim, Yi-Hong Ong, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Carmen Rodriguez, and Keith A. Cengel "A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT", Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 1004709 (21 February 2017); https://doi.org/10.1117/12.2253027
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CITATIONS
Cited by 3 scholarly publications.
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KEYWORDS
Photodynamic therapy

Infrared imaging

Infrared cameras

Light

Navigation systems

Sensors

Light sources

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