LoC-SERS toward clinical application: quantification of antibiotics in human urine samples

I. J. Hidi; M. Jahn; K. Weber; M. W. Pletz; T. W. Bocklitz; D. Cialla-May; J. Popp

doi:10.1117/12.2250533

17 April 2017 LoC-SERS toward clinical application: quantification of antibiotics in human urine samples

I. J. Hidi, M. Jahn, K. Weber, M. W. Pletz, T. W. Bocklitz, D. Cialla-May, J. Popp

Proceedings Volume 10080, Plasmonics in Biology and Medicine XIV; 100800N (2017) https://doi.org/10.1117/12.2250533
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The determination of the concentration of xenobiotics in biological matrix followed by the change of the prescribing procedure plays a major role in the transition from general to personalized medicine. For this contribution, human urine samples collected from healthy volunteers and from patients having urinary tract infection were used as biological matrix to assess the potential and limitation of LoC-SERS to detected levofloxacin and nitroxoline. The determination of both antibiotics at clinically relevant concentrations, 1.38 mM ± 0.68 mM for levofloxacin and 10-40 µM for nitroxoline, will be presented. For quantification purposes the standard addition method is combined with LoC-SERS.

Citation Download Citation

I. J. Hidi, M. Jahn, K. Weber, M. W. Pletz, T. W. Bocklitz, D. Cialla-May, and J. Popp "LoC-SERS toward clinical application: quantification of antibiotics in human urine samples", Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 100800N (17 April 2017); https://doi.org/10.1117/12.2250533

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