Electronic, optical, and chemical interrogation of neural circuits with multifunctional fibers (Conference Presentation)

Andres Canales; Seongjun Park; Chi Lu; Yoel Fink; Polina O. Anikeeva

doi:10.1117/12.2276770

29 September 2017 Electronic, optical, and chemical interrogation of neural circuits with multifunctional fibers (Conference Presentation)

Andres Canales, Seongjun Park, Chi Lu, Yoel Fink, Polina O. Anikeeva

Author Affiliations +

Proceedings Volume 10352, Biosensing and Nanomedicine X; 103520J (2017) https://doi.org/10.1117/12.2276770
Event: SPIE Nanoscience + Engineering, 2017, San Diego, California, United States

Abstract

Despite recent advances in microfabrication and nanofabrication, integrating multiple modes of communication with the brain into a single biocompatible neural probe remains a challenge. These multifunctional neural probes may further our understanding of normal and disrupted functions of neural circuits manifested in neurological conditions, such as Parkinson’s disease. Here, we present a novel family of probes fabricated using a thermal drawing process. In this process, a macroscopic template (preform) containing the desired features is drawn by applying heat and tension into a fiber that conserves the original geometry of the preform but at a much smaller scale. Being composed of soft materials, such as polymers, conductive composites, and low melting temperature metals, fiber based neural probes minimize the damage to the surrounding tissue when implanted. Furthermore, fiber drawing enables straightforward integration features allowing for simultaneous electrical, optical and chemical interrogation of the brain. We demonstrate the utility of these probes for one-step optogenetics, in which a viral vector carrying opsin genes is injected through the same device then used to optically stimulate neurons and record their response as electrical activity. With these probes, we also show, for the first time, recordings of electrical activity in the spinal cord of freely moving mice.

Conference Presentation

Citation Download Citation

Andres Canales, Seongjun Park, Chi Lu, Yoel Fink, and Polina O. Anikeeva "Electronic, optical, and chemical interrogation of neural circuits with multifunctional fibers (Conference Presentation)", Proc. SPIE 10352, Biosensing and Nanomedicine X, 103520J (29 September 2017); https://doi.org/10.1117/12.2276770

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical fibers

Brain

Optogenetics

Tissue optics

Composites

Metals

Microfabrication

Show All Keywords

Keywords/Phrases

Search In:

Publication Years