Probing the dynamics of spontaneous cortical activities via widefield Ca+2 imaging in GCaMP6 transgenic mice

Li Zhu; Christian R. Lee; David J. Margolis; Laleh Najafizadeh

doi:10.1117/12.2274119

21 November 2017 Probing the dynamics of spontaneous cortical activities via widefield Ca⁺² imaging in GCaMP6 transgenic mice

Li Zhu, Christian R. Lee, David J. Margolis, Laleh Najafizadeh

Author Affiliations +

Proceedings Volume 10394, Wavelets and Sparsity XVII; 103940C (2017) https://doi.org/10.1117/12.2274119
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

Studying the temporal and spectral characteristics of brain function under spontaneous activity has been recently receiving great interest in the field of neuroscience. By combining wavelet coherence and multivariate permutation test, this paper presents a new method for investigating changes in functional connectivity under spontaneous activity. The proposed method does not impose any prior assumption about the frequency bands that are involved in the activity, nor on the distribution of the data. The proposed method is applied on data obtained from widefield transcranial calcium imaging of GCaMP6 transgenic mice. Results on how function connectivity corresponding to two forms of spontaneous activity differ across frequency and space are presented.

Citation Download Citation

Li Zhu, Christian R. Lee, David J. Margolis, and Laleh Najafizadeh "Probing the dynamics of spontaneous cortical activities via widefield Ca⁺² imaging in GCaMP6 transgenic mice", Proc. SPIE 10394, Wavelets and Sparsity XVII, 103940C (21 November 2017); https://doi.org/10.1117/12.2274119

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