In vivo vascular flow profiling combined with optical tweezers based blood routing

Robert Meissner; Wade W. Sugden; Arndt F. Siekmann; Cornelia Denz

doi:10.1117/12.2286117

28 July 2017 In vivo vascular flow profiling combined with optical tweezers based blood routing

Robert Meissner, Wade W. Sugden, Arndt F. Siekmann, Cornelia Denz

Proceedings Volume 10413, Novel Biophotonics Techniques and Applications IV; 104130H (2017) https://doi.org/10.1117/12.2286117
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

In vivo wall shear rate is quantified during zebrafish development using particle image velocimetry for biomedical diagnosis and modeling of artificial vessels. By using brightfield microscopy based high speed video tracking we can resolve single heart-beat cycles of blood flow in both space and time. Maximum blood flow velocities and wall shear rates are presented for zebrafish at two and three days post fertilization. By applying biocompatible optical tweezers as an Optical rail we present rerouting of red blood cells in vivo. With purely light-driven means we are able to compensate the lack of proper red blood cell blood flow in so far unperfused capillaries.

Citation Download Citation

Robert Meissner, Wade W. Sugden, Arndt F. Siekmann, and Cornelia Denz "In vivo vascular flow profiling combined with optical tweezers based blood routing", Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130H (28 July 2017); https://doi.org/10.1117/12.2286117

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