Application of spectroscopic methods for the prevention of side effects on patients during chemotherapy (Conference Presentation)

Jürgen Lademann; Maxim E. Darvin; Johannes Schleusener; Gisela Thiede; Thomas Bocklitz; Martina C. Meinke; Sora Jung

doi:10.1117/12.2316588

15 March 2018 Application of spectroscopic methods for the prevention of side effects on patients during chemotherapy (Conference Presentation)

Jürgen Lademann, Maxim E. Darvin, Johannes Schleusener, Gisela Thiede, Thomas Bocklitz, Martina C. Meinke, Sora Jung

Author Affiliations +

Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104930M (2018) https://doi.org/10.1117/12.2316588
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Although chemotherapeutics for cancer treatment are becoming increasingly efficient these days, they often cause severe dermal side effects. Systemically applied doxorubicin is known for inducing free radicals, which leads to the development of the hand-foot syndrome. This syndrome manifests itself through skin irritations, extending from blistering to open wounds. As doxorubicin exhibits a fluorescence signal in the 520-600 nm region if excited at 488 nm, the doxorubicin’s leakage onto the skin surface could be analyzed. It was found that part of the doxorubicin is ejected with the sweat onto the skin surface, where it spreads and penetrates into the skin like topically applied. By topical application of antioxidants, the doxorubicin could be prevented from inducing free radicals in the skin and consequently the hand-foot syndrome. Raman spectroscopy was used to show that the action mechanism of chemotherapeutics not showing fluorescence signals is similar to the action mechanism of doxorubicin.

Conference Presentation

Citation Download Citation

Jürgen Lademann, Maxim E. Darvin, Johannes Schleusener, Gisela Thiede, Thomas Bocklitz, Martina C. Meinke, and Sora Jung "Application of spectroscopic methods for the prevention of side effects on patients during chemotherapy (Conference Presentation)", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930M (15 March 2018); https://doi.org/10.1117/12.2316588

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Skin

Spectroscopy

Luminescence

Cancer

Oncology

Raman spectroscopy

Keywords/Phrases

Search In:

Publication Years