Applications of polarization speckle in skin cancer detection and monitoring

Tim K. Lee; Lioudmila Tchvialeva; Jamie Phillips; Daniel C. Louie; Jianhua Zhao; Wei Wang; Harvey Lui; Sunil Kalia

doi:10.1117/12.2305383

18 January 2018 Applications of polarization speckle in skin cancer detection and monitoring

Tim K. Lee, Lioudmila Tchvialeva, Jamie Phillips, Daniel C. Louie, Jianhua Zhao, Wei Wang, Harvey Lui, Sunil Kalia

Proceedings Volume 10612, Thirteenth International Conference on Correlation Optics; 106121B (2018) https://doi.org/10.1117/12.2305383
Event: Thirteenth International Conference on Correlation Optics, 2017, Chernivtsi, Ukraine

Abstract

Polarization speckle is a rapidly developed field. Unlike laser speckle, polarization speckle consists of stochastic interference patterns with spatially random polarizations, amplitudes and phases. We have been working in this exciting research field, developing techniques to generate polarization patterns from skin. We hypothesize that polarization speckle patterns could be used in biomedical applications, especially, for detecting and monitoring skin cancers, the most common neoplasmas for white populations around the world. This paper describes our effort in developing two polarization speckle devices. One of them captures the Stokes parameters S_o and S₁ simultaneously, and another one captures all four Stokes parameters S_o, S₁, S₂, and S₃ in one-shot, within milliseconds. Hence these two devices could be used in medical clinics and assessed skin conditions in-vivo. In order to validate our hypothesis, we conducted a series of three clinical studies. These are early pilot studies, and the results suggest that the devices have potential to detect and monitor skin cancers.

Citation Download Citation

Tim K. Lee, Lioudmila Tchvialeva, Jamie Phillips, Daniel C. Louie, Jianhua Zhao, Wei Wang, Harvey Lui, and Sunil Kalia "Applications of polarization speckle in skin cancer detection and monitoring", Proc. SPIE 10612, Thirteenth International Conference on Correlation Optics, 106121B (18 January 2018); https://doi.org/10.1117/12.2305383

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