Shape based pharmacokinetic fluorescence optical tomography

Omprakash Gottam; Naren Naik; Sanjay Gambhir

doi:10.1117/12.2319358

24 April 2018 Shape based pharmacokinetic fluorescence optical tomography

Omprakash Gottam, Naren Naik, Sanjay Gambhir

Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 107110M (2018) https://doi.org/10.1117/12.2319358
Event: SPIE Structured Light, 2018, Yokohama, Japan

Abstract

Pharmacokinetic analysis of optical fluorophore provides physiological information of the abnormalities in tissue. Compartment modeling of the fluorophore pharmacokinetics quantify the physiological changes in the tissue. We propose a shape based tomographic reconstruction of pharmacokinetic rates, concentrations and volume fractions of the fluorophore using the time varying near infra-red measurements. Radial basis function based parametric levelsets are used to represent the boundary of the spatially varying parameters of interest. A regularized Gauss-Newton filter based scheme is used reconstruct shape, pharmacokinetic rates, volume fractions and concentration parameters. Reconstruction results for tumor mimicking numerical phantom validate our proposed approach.

Citation Download Citation

Omprakash Gottam, Naren Naik, and Sanjay Gambhir "Shape based pharmacokinetic fluorescence optical tomography", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110M (24 April 2018); https://doi.org/10.1117/12.2319358

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