Arbitrary phase shifting in diffraction common path interferometry

Fatemeh HadavandMirzaee; Desmond Williams; Thomas Suleski; Rosario Porras-Aguilar

doi:10.1117/12.2320856

18 August 2018 Arbitrary phase shifting in diffraction common path interferometry

Fatemeh HadavandMirzaee, Desmond Williams, Thomas Suleski, Rosario Porras-Aguilar

Proceedings Volume 10749, Interferometry XIX; 107490V (2018) https://doi.org/10.1117/12.2320856
Event: SPIE Optical Engineering + Applications, 2018, San Diego, California, United States

Abstract

Quantitative phase imaging (QPI) has made a tremendous contribution to microbiology and medicine. Recently, QPI has been used for in-vitro fertilization optimization, and cell culture monitoring, among others. These accomplishments have been made using phase measurements. QPI is based on well-known optical metrology techniques. The challenge in QPI is developing phase measuring systems that can be used in the medical or microbiological environment. For such applications, two-beam interferometers are not suitable. In this context, we propose a common path interferometric system that provides quantitative phase measurements. The method combines the diffraction phase microscopy with the arbitrary phase shifting technique. The phase-shifted images are obtained by means of a shifted diffraction grating and an amplitude filter that allows interference between the undiffracted light and the first spatial frequency at the Fourier plane. The results show a reduction in the noise of the resultant phase when using the arbitrary phase shifting technique. This system can potentially be used to quantify nanoscale motions in living cells.

Conference Presentation

Citation Download Citation

Fatemeh HadavandMirzaee, Desmond Williams, Thomas Suleski, and Rosario Porras-Aguilar "Arbitrary phase shifting in diffraction common path interferometry", Proc. SPIE 10749, Interferometry XIX, 107490V (18 August 2018); https://doi.org/10.1117/12.2320856

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