Multiphoton imaging of gastric intestinal metaplasia

Lianhuang Li; Deyong Kang; Changyin Feng; Zhenlin Zhan; Shuangmu Zhuo; Yongjian Zhou; Jianxin Chen

doi:10.1117/12.2500391

23 October 2018 Multiphoton imaging of gastric intestinal metaplasia

Lianhuang Li, Deyong Kang, Changyin Feng, Zhenlin Zhan, Shuangmu Zhuo, Yongjian Zhou, Jianxin Chen

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108201F (2018) https://doi.org/10.1117/12.2500391
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Intestinal metaplasia has been widely considered as a precursor of gastric cancer, and early detection and accurate diagnosis will have important clinical significance. Therefore, multiphoton microscopy using two-photon excited fluorescence combined with second harmonic generation was used for investigating gastric intestinal metaplasia in this work, and imaging results showed that this microscope has the ability to directly differentiate this lesion in the absence of labels. This study highlights the potential of multiphoton microscopy as a diagnostic tool for label-freely identifying gastric intestinal metaplasia.

Citation Download Citation

Lianhuang Li, Deyong Kang, Changyin Feng, Zhenlin Zhan, Shuangmu Zhuo, Yongjian Zhou, and Jianxin Chen "Multiphoton imaging of gastric intestinal metaplasia", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108201F (23 October 2018); https://doi.org/10.1117/12.2500391

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