Metronidazole-substituted dendrimer silicon phthalocyanine: a novel photodynamic therapy photosensitizer

Qiuhao Ye; Xiangyi Han; Di Zeng; Hongqin Yang; Yiru Peng

doi:10.1117/12.2500889

23 October 2018 Metronidazole-substituted dendrimer silicon phthalocyanine: a novel photodynamic therapy photosensitizer

Qiuhao Ye, Xiangyi Han, Di Zeng, Hongqin Yang, Yiru Peng

Author Affiliations +

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 1082029 (2018) https://doi.org/10.1117/12.2500889
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

As an excellent second-generation photosensitizer for photodynamic therapy (PDT), phthalocyanine (Pc) complex has strong absorption peak in the near-infrared region and strong tissue penetrating ability, which endowed them excellent properties for the detection of tumor tissue. In recent years, in order to further ehnaced the penetration depth of the photosensitizer to the tissue, a large number of functional groups have been synthesized . In this work, we designed and synthesized metronidazole-substituted dendrimer silicon phthalocyanine (MT-SiPc) with near-infrared region Q-band of UV absorption, excellent fluorescence properties and photochemical properties.

Citation Download Citation

Qiuhao Ye, Xiangyi Han, Di Zeng, Hongqin Yang, and Yiru Peng "Metronidazole-substituted dendrimer silicon phthalocyanine: a novel photodynamic therapy photosensitizer", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 1082029 (23 October 2018); https://doi.org/10.1117/12.2500889

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