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In this paper, we summarize our recent advances in the development and pre-clinical testing of the 2-nd generation OCT-based probe for core needle biopsy guidance. The acquired OCT images are processed in real-time in a GPU unit to provide the interventional radiologist with the capability to examine the tissue cellularity at the tip of the biopsy needle before deciding to take a biopsy core. The extensive testing of this technology on a rabbit model of soft tissue cancer is discussed in detail. The pre-clinical results demonstrate the capability of this OCT-based probe for determining the in situ cellularity of the tissue at the tip of the biopsy needle and thus its potential use for improving the quality of the sampled biopsy cores.
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Nicusor V. Iftimia, Gopi Maguluri, Jesung Park, Sharjeel Sabir, "OCT for core biopsy guidance: a rabbit study (Conference Presentation)," Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730F (4 March 2019); https://doi.org/10.1117/12.2508135