CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10875 > Article
Presentation
4 March 2019 Laser-induced liquid micro-jets for needle-free injection into biological tissue (Conference Presentation)
Jan Krizek, Paul Delrot, Christophe Moser
Author Affiliations +
Proceedings Volume 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII; 1087512 (2019) https://doi.org/10.1117/12.2509555
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Fast liquid jets (<150 m/s) are used as a needle-free fluid injection into elastomeric tissue such as skin. Because the fluid droplets are smaller than a typical needle diameter, there is less collateral damage caused by the jets in the intervened body. In this study, we aim to investigate the potential of the method to deliver liquids into biological tissues with higher stiffness than skin. To address this challenge we have implemented an optofluidic jetting system capable of generating supersonic liquid microjets driven by laser cavitation. Considering microfluidic properties of the system, we have exceeded a method to produce jets in a repetitive regime with rates of up to 6 Hz, diameters of 10, 15 and 30 µm and velocities exceeding 550 m/s. We have characterized the injection depth with respect to jet speed, jet diameter and elastic modulus of the sample material. Experiments were performed on hydrogels with Young’s modulus from 8 kPa to 1 MPa, which covers the wide spectrum of biological elastomers like inner body organ tissues, blood vessels, skin or cartilage.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Jan Krizek, Paul Delrot, and Christophe Moser "Laser-induced liquid micro-jets for needle-free injection into biological tissue (Conference Presentation)", Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 1087512 (4 March 2019); https://doi.org/10.1117/12.2509555
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Liquids
Laser tissue interaction
Microfluidics
Skin
Tissues
Blood vessels
Cartilage
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top