Non-contact optical wavefront shaping for focusing light and high-resolution imaging inside and behind biological scattering medium

Abhijit Sanjeev; Yuval Kapellner; Nadav Shbero; Eran Gur; Zeev Zalevsky

doi:10.1117/12.2507797

4 March 2019 Non-contact optical wavefront shaping for focusing light and high-resolution imaging inside and behind biological scattering medium

Abhijit Sanjeev, Yuval Kapellner, Nadav Shbero, Eran Gur, Zeev Zalevsky

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Proceedings Volume 10932, Emerging Digital Micromirror Device Based Systems and Applications XI; 1093204 (2019) https://doi.org/10.1117/12.2507797
Event: SPIE OPTO, 2019, San Francisco, California, United States

Abstract

Optical wavefront shaping is one of the most effective techniques in focusing light inside a scattering medium. Unfortunately, most of these techniques require direct access to the scattering medium or need to know the scattering properties of the medium beforehand. Through our scheme we develop a novel concept in which both the illumination and the detection is on the same side of the inspected object and the imaging process is a real time fast converging operation that does not require to capture large plurality of images. We model the scattering medium being a biological tissue as a Matrix having mathematical properties matched to the physical and biological aspects of the sample. In our adaptive optics scheme, we aim to estimate the scattering function and thus to encode the intensity of the illuminating laser light source using DMD (Digital Micromirror Device) with an inverse scattering function of the scattering medium, such that after passing its scattering function a focused beam is obtained. We optimize the pattern to be displayed on the DMD using Particle Swarm Algorithm (PSO). As first proof of concept we show validation via numerical MATLAB simulations where we obtain a focused spot behind a scattering medium in amplitude modulation scheme.

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Abhijit Sanjeev, Yuval Kapellner, Nadav Shbero, Eran Gur, and Zeev Zalevsky "Non-contact optical wavefront shaping for focusing light and high-resolution imaging inside and behind biological scattering medium", Proc. SPIE 10932, Emerging Digital Micromirror Device Based Systems and Applications XI, 1093204 (4 March 2019); https://doi.org/10.1117/12.2507797

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KEYWORDS

Scattering

Light scattering

Scattering media

Wavefronts

Digital micromirror devices

Spatial light modulators

Biomedical optics

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