Dynamic optical contrast imaging (DOCI): system theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism

Harrison Cheng; Yao Xie; Peter Pellionisz; Aidan Pearigen; Khuzaima Rangwalla; Oscar Stafsudd; Zachary Taylor; Maie St. John; Warren Grundfest

doi:10.1117/12.2513823

8 March 2019 Dynamic optical contrast imaging (DOCI): system theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism

Harrison Cheng, Yao Xie, Peter Pellionisz, Aidan Pearigen, Khuzaima Rangwalla, Oscar Stafsudd, Zachary Taylor, Maie St. John, Warren Grundfest

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Proceedings Volume 10951, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling; 109512T (2019) https://doi.org/10.1117/12.2513823
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Dynamic Optical Contrast Imaging (DOCi) is an imaging technique that generates image contrast through ratiometric measurements of the autouflorescence decay rates of aggregate uorophores in tissue. This method enables better tissue characterization by utilizing wide-field signal integration, eliminating constraints of uniform illumination, and reducing time-intensive computations that are bottlenecks in the clinical translation of traditional fluorescence lifetime imaging. Previous works have demonstrated remarkable tissue contrast between tissue types in clinical human pilot studies [Otolaryngology-Head and Neck Surgery 157, 480 (2017)]. However, there are still challenges in the development of several subsystems, which results in existing works to use relative models. A comprehensive mathematical framework is presented to describe the contrast mechanism of the DOCi system to allow intraoperative quantitative imaging, which merits consideration for evaluation in measuring tissue characteristics in several important clinical settings.

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Harrison Cheng, Yao Xie, Peter Pellionisz, Aidan Pearigen, Khuzaima Rangwalla, Oscar Stafsudd, Zachary Taylor, Maie St. John, and Warren Grundfest "Dynamic optical contrast imaging (DOCI): system theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism", Proc. SPIE 10951, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 109512T (8 March 2019); https://doi.org/10.1117/12.2513823

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KEYWORDS

Luminescence

Tissues

Imaging systems

Data modeling

Convolution

Mathematical modeling

Optical imaging

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