Tomosynthesis method for depth resolution of beta emitters

Thomy Mertzanidou; Nick Calvert; David Tuch; Danail Stoyanov; Simon Arridge

doi:10.1117/12.2511753

15 March 2019 Tomosynthesis method for depth resolution of beta emitters

Thomy Mertzanidou, Nick Calvert, David Tuch, Danail Stoyanov, Simon Arridge

Proceedings Volume 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging; 109531G (2019) https://doi.org/10.1117/12.2511753
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

The motivation of this study derives from the need for tumour margin estimation after surgical excision. Conventional beta autoradiography of beta emitters can be used to image tissue sections providing high spatial resolution compared to in-vivo molecular imaging. However, it requires sectioning of the specimen and it provides a 2D image of the tissue. Imaging of the 3D tissue sample can be achieved either by imaging sequential 2D sections, which is time-consuming and laborious, or by using a specialised detector for imaging that records the particles’ direction, in addition to their position, when they hit the detector. In this work we investigate whether a novel beta-tomosynthesis approach can be used for depth resolution of beta emitters. The technique involves acquiring multiple 2D images of the intact tissue sample while the detector rotates around the sample. The images are then combined and used to reconstruct the 3D position of the sources from a limited angle of conventional 2D autoradiography images. We present the results from Geant4 forward simulations and the reconstructed images from a breast tissue sample containing a Fluorine-18 positron emission source. The experiments show that the proposed method can provide depth resolution under certain conditions, indicating that there is potential for its use as a 3D molecular imaging technique of surgical samples in the future.

Conference Presentation

Citation Download Citation

Thomy Mertzanidou, Nick Calvert, David Tuch, Danail Stoyanov, and Simon Arridge "Tomosynthesis method for depth resolution of beta emitters", Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 109531G (15 March 2019); https://doi.org/10.1117/12.2511753

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available