NIR transillumination system for in vivo functional imaging

Sabina Merlo; Valentina Bello; Elisabetta Bodo; Rachele Catalano; Sara Pizzurro; Marco Rossi Borghesano

doi:10.1117/12.2520116

11 April 2019 NIR transillumination system for in vivo functional imaging

Sabina Merlo, Valentina Bello, Elisabetta Bodo, Rachele Catalano, Sara Pizzurro, Marco Rossi Borghesano

Proceedings Volume 11028, Optical Sensors 2019; 1102810 (2019) https://doi.org/10.1117/12.2520116
Event: SPIE Optics + Optoelectronics, 2019, Prague, Czech Republic

Abstract

In this work, we reconsider optical transillumination for in vivo tissue imaging and for detection of time-dependent vital signs. Two portable optoelectronic instrumental configurations have been assembled and tested to achieve efficient transillumination and image detection of the inner structure of diffusing non-homogeneous biological samples with thickness of a few centimeters, with a resolution sufficient for differentiating internal macroscopic tissue structures. Tissue illumination is obtained with an extended source consisting in a matrix of Near Infra-Red (NIR) light emitters. To demonstrate the potentiality of this system for generating low resolution images of in vivo human tissues, it has been employed for transilluminating human upper limbs. Images featuring good contrast are acquired non-invasively with a monochrome CMOS camera turned into a wavelength selective image detector using optical filters. The collected images of human hands provide a clear visualization of the hand dorsal vein pattern. From recorded videos, we extract a timevarying signal that closely resembles the blood pressure wave: in its spectral content we recognize the frequency components corresponding to the expected heart and breath rates.

Citation Download Citation

Sabina Merlo, Valentina Bello, Elisabetta Bodo, Rachele Catalano, Sara Pizzurro, and Marco Rossi Borghesano "NIR transillumination system for in vivo functional imaging", Proc. SPIE 11028, Optical Sensors 2019, 1102810 (11 April 2019); https://doi.org/10.1117/12.2520116

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