Infrared spectroscopy evaluation of burn wound healing: semi-quantitative study

Pedro A. A. de Castro; Denise M. Zezell

doi:10.1117/12.2527051

19 July 2019 Infrared spectroscopy evaluation of burn wound healing: semi-quantitative study

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 1107304 (2019) https://doi.org/10.1117/12.2527051
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Wound healing is a biological response in order to recover the tissue stability after injury. The impaired healing by third-degree, when the damage achieves the major part of dermis, is defined in four sequential and overlapping phases: Inflammation, transition, proliferative and maturative¹. The role of biochemical cascade associated in each phase are still not fully understood, thus systematic evaluations tests are crucial. In fact, the gold standard to interrogate the molecular signature of wound healing is concern on immunohistochemical analysis. This approach tends to be laborious, time-consuming and require multiple assays². Since Fourier transform infrared spectroscopy (FTIR) has been demonstrated in other studies to provide molecular change report upon biological samples, the present study aims to estimate the feasibility of FTIR to discriminate healthy and burned skin throughout wound stages.

Citation Download Citation

Pedro A. A. de Castro and Denise M. Zezell "Infrared spectroscopy evaluation of burn wound healing: semi-quantitative study", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 1107304 (19 July 2019); https://doi.org/10.1117/12.2527051

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