Classification and identification of human colon cancer cell line in terahertz domain using t-SNE

Guangxin Zhang; Yuqi Cao; Jiani Chen; Pingjie Huang; Weiting Ge; Dibo Hou

doi:10.1117/12.2526698

19 July 2019 Classification and identification of human colon cancer cell line in terahertz domain using t-SNE

Guangxin Zhang, Yuqi Cao, Jiani Chen, Pingjie Huang, Weiting Ge, Dibo Hou

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 110731A (2019) https://doi.org/10.1117/12.2526698
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Terahertz time-domain spectroscopy (THz-TDS) has been applied to medical applications as THz waves are sensitive to biomolecules. In this paper, terahertz time-domain attenuated total reflection spectroscopy (THz-ATR) was used to identify human colon cancer cell line. The refractive indices of cancerous and normal cell lines with six different concentrations were analyzed in the frequency domain from 0.1-1.2THz. t-Distributed Stochastic Neighbor Embedding (t-SNE) and Principal Components Analysis (PCA) methods were adopted to extract the key features from the THz spectrum. Experimental results showed that the features extracted by t-SNE had better recognition accuracy owing to enhanced clustering efficacy. This work may be helpful for detecting human colon cancer cells by using terahertz techniques.

Citation Download Citation

Guangxin Zhang, Yuqi Cao, Jiani Chen, Pingjie Huang, Weiting Ge, and Dibo Hou "Classification and identification of human colon cancer cell line in terahertz domain using t-SNE", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110731A (19 July 2019); https://doi.org/10.1117/12.2526698

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