Deformable and reconfigurable mouse phantoms with 3D printing and LTS technologies

Hannah Wang; Mengzhou Li; Matthew Getzin; Brigitte L. Arduini; Nathaniel Covert; Deepak Vashishth; Paul Fitzgerald

doi:10.1117/12.2530770

10 September 2019 Deformable and reconfigurable mouse phantoms with 3D printing and LTS technologies

Hannah Wang, Mengzhou Li, Matthew Getzin, Brigitte L. Arduini, Nathaniel Covert, Deepak Vashishth, Paul Fitzgerald

Proceedings Volume 11113, Developments in X-Ray Tomography XII; 111131S (2019) https://doi.org/10.1117/12.2530770
Event: SPIE Optical Engineering + Applications, 2019, San Diego, California, United States

Abstract

Mice are used for models of almost all human diseases and are routinely scanned by micro-CT scanners. Mouse phantoms are often used for image-quality assessment. With recent developments in deep-learning-based preclinical imaging, there is a major need for large micro-CT datasets in which ground truth is known. In this study, we investigate the feasibility of making cost-effective deformable and reconfigurable mouse phantoms to generate real micro-CT datasets that reflect realistic underlying physical characteristics. Such datasets are highly desirable; for example, complicated photon-counting micro-CT datasets are needed for deep-learning-based material decomposition. In our scheme, mouse body parts are 3Dprinted with high precision using rigid or flexible materials. Liquid tissue surrogates (LTSs) or bioinks/cell lines could be used to emulate mouse organs and physiological fluid in the animals. LTSs provide realistic x-ray properties of their biological counterparts. The LTS organs could be contained in not only 3D-printed chambers, but also dialysis tubing, which emulates the cell membrane. Furthermore, through bioprinting and tissue engineering, organs and tissues can be made even more realistic for micro-CT and other types of tomographic scanning.

Citation Download Citation

Hannah Wang, Mengzhou Li, Matthew Getzin, Brigitte L. Arduini, Nathaniel Covert, Deepak Vashishth, and Paul Fitzgerald "Deformable and reconfigurable mouse phantoms with 3D printing and LTS technologies", Proc. SPIE 11113, Developments in X-Ray Tomography XII, 111131S (10 September 2019); https://doi.org/10.1117/12.2530770

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