Simulation of spatial and temporal distribution of singlet oxygen in port wine stain during vascular targeted photodynamic therapy

Linxin Li; Lina Liu; Ying Wang; Ying Gu; Buhong Li

doi:10.1117/12.2537441

20 November 2019 Simulation of spatial and temporal distribution of singlet oxygen in port wine stain during vascular targeted photodynamic therapy

Linxin Li, Lina Liu, Ying Wang, Ying Gu, Buhong Li

Author Affiliations +

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 111902D (2019) https://doi.org/10.1117/12.2537441
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Vascular-targeted photodynamic therapy (V-PDT) has been demonstrated to be an effective treatment modality for nonmalignant diseases such as capillary malformations port wine stains (PWS). V-PDT treatment of PWS involves a complex interaction of light, photosensitizer (PS), oxygen and biological tissue. A three-dimensional (3D) model of PWS with a Y-bifurcation blood vessels was proposed for mathematical simulation of the spatial and temporal distribution of singlet oxygen (¹O₂), which related to the distribution of light, PS and oxygen. A graphics processing units (GPU)-based method, Monte Carlo eXtreme (MCX), was applied to calculate the light deposition in the PWS, and a set of differential equations were utilized to describe the photochemical reactions involved in V-PDT. Using the obtained light energy deposition and the distributions of the PS and oxygen, a dynamic change model of the cumulative concentration of ¹O₂ ([¹O₂]) was estimated. The data show that the smaller vessels are more likely to acquire more [¹O₂].

Citation Download Citation

Linxin Li, Lina Liu, Ying Wang, Ying Gu, and Buhong Li "Simulation of spatial and temporal distribution of singlet oxygen in port wine stain during vascular targeted photodynamic therapy", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111902D (20 November 2019); https://doi.org/10.1117/12.2537441

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Oxygen

Blood vessels

Picosecond phenomena

Photodynamic therapy

3D modeling

Monte Carlo methods

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years