Research on ischemia-reperfusion injury of rat kidney using optical coherence tomography

Yuhong Fang; Wei Gong; Zheng Huang; Liqin Zheng; Hongxin Lin; Deyuan Yang; Shusen Xie

doi:10.1117/12.2537737

20 November 2019 Research on ischemia-reperfusion injury of rat kidney using optical coherence tomography

Yuhong Fang, Wei Gong, Zheng Huang, Liqin Zheng, Hongxin Lin, Deyuan Yang, Shusen Xie

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 1119032 (2019) https://doi.org/10.1117/12.2537737
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Renal artery occlusion is an unavoidable process during operations such as nephrectomy, carcinoma resection, kidney transplantation and so on. For minimizing the kidney injury, the optimal renal ischemia time was experimentally investigated. Optical coherence tomography (OCT) is a high resolution imaging modality can non-invasively image biotissue in vivo and in real time. In order to study the relationship between tubular injury and the renal ischemia time, OCT images of Wistar rat kidneys endured various ischemia time were obtained throughout the whole ischemia-reperfusion procedure. The tubular density and the average diameter of uriniferous tubules were considered as biomarker of kidney activity, and the quantitative results well described the degree of kidney injury.

Citation Download Citation

Yuhong Fang, Wei Gong, Zheng Huang, Liqin Zheng, Hongxin Lin, Deyuan Yang, and Shusen Xie "Research on ischemia-reperfusion injury of rat kidney using optical coherence tomography", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 1119032 (20 November 2019); https://doi.org/10.1117/12.2537737

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