Finite element modeling of mechanical properties of cancer cells

Jiangbing Mao; Weiwei Ruan; Mengdan Chen; Yuhua Wang; Hongqin Yang

doi:10.1117/12.2537819

20 November 2019 Finite element modeling of mechanical properties of cancer cells

Jiangbing Mao, Weiwei Ruan, Mengdan Chen, Yuhua Wang, Hongqin Yang

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 1119038 (2019) https://doi.org/10.1117/12.2537819
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Cellular mechanical properties are an important indicator for assessing and analyzing the functions of cells. However, the structure and compositions of the cell are complex. In order to analyze the effects of different components on the mechanical properties of cells, a multi-structured 3D model of cancer cells considering the cytoskeleton, cytoplasm, nucleus and cell membrane was established by finite element method. And the tensegrity structure-finding algorithm was used to analyze the cytoskeletal distribution and the pre-stress of each component. First, the model was verified by comparing numerical results with force-indentation curve obtained by atomic force microscopy in Ho-8910 cells. Then, the elasticity modulus of cell were obtained via applying a load to the established model.Computational simulation showed that cytoskeleton are the major component targeted in resisting compression.In addition, this model can provide useful guidance for the measurement and analysis of single cell through atomic force microscopy.

Citation Download Citation

Jiangbing Mao, Weiwei Ruan, Mengdan Chen, Yuhua Wang, and Hongqin Yang "Finite element modeling of mechanical properties of cancer cells", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 1119038 (20 November 2019); https://doi.org/10.1117/12.2537819

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