A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery (Conference Presentation)

Steven M. Blair; Amit Deliwala; Eric Chen; Sailesh Subashbabu; Anthony Li; Mebin George; Missael Garcia; Nan Cui; Viktor Gruev

doi:10.1117/12.2545389

10 March 2020 A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery (Conference Presentation)

Steven M. Blair, Amit Deliwala, Eric Chen, Sailesh Subashbabu, Anthony Li, Mebin George, Missael Garcia, Nan Cui, Viktor Gruev

Author Affiliations +

Proceedings Volume 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI; 112220A (2020) https://doi.org/10.1117/12.2545389
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Near-infrared fluorescence image-guided surgery offers substantial benefits for both surgeons and patients, but high-performance near-infrared fluorescent molecular markers are not available for clinical application. To enable adoption of a wider variety of fluorescent markers, we have developed a single-chip snapshot multispectral imaging system that combines a scientific CMOS image sensor with high quantum efficiency (94%), low read noise (1.6 e-), and high dynamic range (91 dB) and pixelated interference filters that enable color/near-infrared imaging without co-registration error The fully integrated imaging system is currently being evaluated for tumor detection with targeted probes and sentinel lymph node detection with indocyanine green.

Conference Presentation

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Steven M. Blair, Amit Deliwala, Eric Chen, Sailesh Subashbabu, Anthony Li, Mebin George, Missael Garcia, Nan Cui, and Viktor Gruev "A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220A (10 March 2020); https://doi.org/10.1117/12.2545389

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KEYWORDS

Imaging systems

Image-guided intervention

Luminescence

Multispectral imaging

Image sensors

Quantum efficiency

CMOS sensors

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