Cherenkov emission from external beam irradiation: proportional to the dose buildup gradient and inversely affected by tissue optical attenuation

Brian W. Pogue; Rachael L. Hachadorian; Sadhya Garg; Jacqueline Andreozzi; Petr Bruza

doi:10.1117/12.2548155

25 February 2020 Cherenkov emission from external beam irradiation: proportional to the dose buildup gradient and inversely affected by tissue optical attenuation

Brian W. Pogue, Rachael L. Hachadorian, Sadhya Garg, Jacqueline Andreozzi, Petr Bruza

Author Affiliations +

Proceedings Volume 11224, Optics and Ionizing Radiation; 112240D (2020) https://doi.org/10.1117/12.2548155
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Cherenkov light emission from tissue undergoing radiation therapy is a complex function of the dose deposition and is reduced by the optical attenuation of the tissue. A diffusion theory based integral of the remitted light is presented, using the assumption that only Cherenkov photons from the first 8 mm of tissue are able to appreciably escape from the surface. This depth restriction falls within the linear build-up region for both electron and photon beams used in radiotherapy. The resulting expression for Cherenkov light fluence formulated here indicates that the outgoing intensity is dependent upon the quasi-linear dose build up gradient (k₂) in the first 8 mm of tissue, is inversely proportional to the optical absorption (μ_a), and is relatively independent of the scattering coefficient (μ_s ^/ ). Numerical evaluation suggests that the diffuse component of Cherenkov light emission dominates over any unscattered photons, suggesting that the radiation build-up factor dominates what is imaged off the surface. This observation could allow for linear corrections to Cherenkov images with knowledge of tissue optical properties and for better interpretation of the origin of Cherenkov from tissue.

Citation Download Citation

Brian W. Pogue, Rachael L. Hachadorian, Sadhya Garg, Jacqueline Andreozzi, and Petr Bruza "Cherenkov emission from external beam irradiation: proportional to the dose buildup gradient and inversely affected by tissue optical attenuation", Proc. SPIE 11224, Optics and Ionizing Radiation, 112240D (25 February 2020); https://doi.org/10.1117/12.2548155

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available