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We introduce Optofluidic PlasmonIC (OPtIC) microlenses to overcome the shortcomings of existing optical chromatography techniques by eliminating the need for sophisticated instrumentation and pre- cise alignment requirements. Our sub-wavelength thick (~200 nm thick) OPtIC microlenses offer objective-free focusing and self-alignment of optical and fluidic drag forces and present a facile platform for selective separation of exosome size bioparticles. By allowing direct coupling of collimated broadband light to realize strong optical scattering forces at a focal point, extremely small footprint (4 μm × 4 μm) OPtIC microlenses open the door for drastically multiplexed optical chromatography and high-throughput sample processing capability.
Xiangchao Zhu,Ahmet Cicek,Yixiang Li, andAhmet Ali Yanik
"Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)", Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 112350T (9 March 2020); https://doi.org/10.1117/12.2547106
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Xiangchao Zhu, Ahmet Cicek, Yixiang Li, Ahmet Ali Yanik, "Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)," Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 112350T (9 March 2020); https://doi.org/10.1117/12.2547106