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20 April 2020 Toward whole-brain in vivo optoacoustic angiography of rodents (Conference Presentation)
Pavel Vladimirovich Subochev, Ilya V. Turchin
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Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112400O (2020) https://doi.org/10.1117/12.2551060
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We report on a comprehensive theoretical analysis of the optimal wavelengths for in vivo optoacoustic angiography in whole rodent brains. Governed by the competing processes of light attenuation through the brain tissues and optoacoustic signal generation due to absorption by blood, we identified three distinct spectral ranges centered around 580, 895 and 1100 nm optimally suited for imaging of vessels of different size and depth. The developed model was employed for numerical simulation of optoacoustic imaging of murine brain illustrating the effect of probing wavelength on visibility of the cerebral vasculature. In vivo imaging experiments further affirmed the capacity for whole-brain optoacoustic angiography in rodents at a wavelength of 1064nm.
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Pavel Vladimirovich Subochev and Ilya V. Turchin "Toward whole-brain in vivo optoacoustic angiography of rodents (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400O (20 April 2020); https://doi.org/10.1117/12.2551060
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KEYWORDS
Optoacoustics
Angiography
Brain
In vivo imaging
Neuroimaging
Acoustics
Diffusion
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