Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)

Joel W. Y. Tan; Jeff Folz; Raoul Kopelman; Xueding Wang

doi:10.1117/12.2545205

20 April 2020 Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)

Joel W. Y. Tan, Jeff Folz, Raoul Kopelman, Xueding Wang

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112402B (2020) https://doi.org/10.1117/12.2545205
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Recently, Eil et al. showed that tumors with necrotic cores had elevated K+ concentrations due to the release of K+ by necrosis, which acts to suppress T-cell function by high extracellular K+ concentration. These findings demonstrate the importance of developing a tool for imaging K+ distributions. Here, we demonstrate K+ nanosensor-enabled photoacoustic imaging for measuring K+ levels in vivo. The nanosensor is an in-house synthesized optical contrast agent that is sensitive to K+ levels within biological ranges. The use of this K+ nanosensor, combined with multi-spectral photoacoustic imaging, allowed measurement of K+ levels in vivo.

Conference Presentation

Citation Download Citation

Joel W. Y. Tan, Jeff Folz, Raoul Kopelman, and Xueding Wang "Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402B (20 April 2020); https://doi.org/10.1117/12.2545205

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available