Laser speckle micro-rheology for biomechanical profiling of breast cancer (Conference Presentation)

Zeinab Hajjarian Kashany; Elena F. Brachtel; Diane M. Tshikudi; Seemantini K. Nadkarni

doi:10.1117/12.2545055

9 March 2020 Laser speckle micro-rheology for biomechanical profiling of breast cancer (Conference Presentation)

Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane M. Tshikudi, Seemantini K. Nadkarni

Proceedings Volume 11242, Optical Elastography and Tissue Biomechanics VII; 112420D (2020) https://doi.org/10.1117/12.2545055
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Breast neoplasia is accompanied by a heterogeneous micromechanical remodeling of the tumor landscape. Nevertheless, the role of these micromechanical heterogeneities in the progression of invasive breast carcinoma remains unclear. We have developed a novel optical tool, termed laser speckle microrheology (LSM) for micro-mechanical mapping of the tissue to investigate mechano-pathological features of breast cancer progression. Results reveal distinct micromechanical properties both between tumor of different diagnosis and within various regions of each tumor. Additionally, distinct stiffness gradients are observed at the interface of tumors with different invasive potential. Taken together, these findings identify key micromechanical features involved in breast cancer progression.

Conference Presentation

Citation Download Citation

Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane M. Tshikudi, and Seemantini K. Nadkarni "Laser speckle micro-rheology for biomechanical profiling of breast cancer (Conference Presentation)", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 112420D (9 March 2020); https://doi.org/10.1117/12.2545055

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