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Blood flow dynamics in the human retina can be assessed by laser Doppler perfusion imaging by digital holography with near-infrared light, but motion and aberrations of the eye can prevent accurate coherent image formation with standard free-space wave propagation methods. We present a fully digital aberration correction scheme in post-processing by tuning a multi-parameter phase mask in the reciprocal plane of the retina, through iterative optimization of the quality of power Doppler images. The parameters are the amplitudes of low-order Zernike polynomials controlling shift/tilt, defocus and astigmatism. Numerical correction for motion and ametropia reveals smaller vessels than standard reconstruction.
Michael Atlan,Armand Touminet,Thomas Andal,Leo Puyo, andMichel Pâques
"Image-based digital motion and aberration compensation in laser Doppler holography of the eye fundus (Conference Presentation)", Proc. SPIE 11248, Adaptive Optics and Wavefront Control for Biological Systems VI, 112480N (11 March 2020); https://doi.org/10.1117/12.2543944
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Michael Atlan, Armand Touminet, Thomas Andal, Leo Puyo, Michel Pâques, "Image-based digital motion and aberration compensation in laser Doppler holography of the eye fundus (Conference Presentation)," Proc. SPIE 11248, Adaptive Optics and Wavefront Control for Biological Systems VI, 112480N (11 March 2020); https://doi.org/10.1117/12.2543944