2 March 2020Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Terahertz (THz) spectroscopy is expected as a new technique for nondestructive inspection of pharmaceutical tablets, because THz waves pass through a wide variety of pharmaceutical materials. We have been developing a frequency domain THz spectrometer with an injection-seeded THz parametric generation (is-TPG) technique. In this study, the frequency range of the spectrometer was successfully expanded to 0.9-4.2 THz by generating widely tunable THz waves by shifting a nonlinear crystal to balance gain and absorption of the THz waves in the crystal, and detecting the THz waves with an angle-compensation method that utilized the dispersion of the crystal. Absorption spectra of the crystal polymorphs of carbamazepine forms I and III were obtained with the THz spectrometer, and these polymorphs were identified by specific absorption peaks related to their solid state.
M. Mohara,K. Shimura,K. Aiko, andT. Ono
"Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials", Proc. SPIE 11279, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XIII, 112790X (2 March 2020); https://doi.org/10.1117/12.2541794
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
M. Mohara, K. Shimura, K. Aiko, T. Ono, "Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials," Proc. SPIE 11279, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XIII, 112790X (2 March 2020); https://doi.org/10.1117/12.2541794