A mechatronic guidance system for positron emission mammography and ultrasound-guided breast biopsy

Claire K. Park; Jeffrey Bax; Lori Gardi; Aaron Fenster

doi:10.1117/12.2549731

16 March 2020 A mechatronic guidance system for positron emission mammography and ultrasound-guided breast biopsy

Claire K. Park, Jeffrey Bax, Lori Gardi, Aaron Fenster

Proceedings Volume 11315, Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling; 113151B (2020) https://doi.org/10.1117/12.2549731
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Image-guided biopsy is crucial for diagnosis, staging, and treatment planning of women with breast cancer. Conventional imaging modalities to guide breast biopsy are not optimal, often resulting in inconclusive or false-negative diagnosis. High-resolution breast-specific functional imaging using positron emission mammography (PEM) has demonstrated increased sensitivity and diagnostic accuracy for detecting breast tumours compared to conventional modalities. PEM shows potential to be an optimal method for tumour detection, but anatomical reference and visualization for needle guidance are not available for guiding biopsy. This paper reports on the development of a mechatronic guidance system designed for integration with an advanced PEM system and ultrasound (US) to improve sampling accuracy during imageguided breast biopsy. The system contains a mechatronic guidance arm and biopsy device, with an integrated US transducer and core-needle biopsy gun. Custom software modules were developed for 3D needle tracking and user guidance. To validate and demonstrate the utility of its system components, the mechatronic guidance arm and biopsy device were assessed using a simulated PEM detector plate. Registration to the simulated detector plate and validation demonstrates accurate needle tracking with a mean Target Registration Error <1mm. Biopsy accuracy was evaluated under ideal detection and mechatronic guidance conditions using tissue-mimicking breast phantoms, allowing targets <1mm to be sampled within 95% confidence. Our results show feasibility for the mechatronic guidance system to be integrated with PEM and US for accurate image-guided breast biopsy. Current work focuses on evaluating the complete mechatronic system ability to accurately guide, target, and biopsy simulated breast lesions.

Citation Download Citation

Claire K. Park, Jeffrey Bax, Lori Gardi, and Aaron Fenster "A mechatronic guidance system for positron emission mammography and ultrasound-guided breast biopsy", Proc. SPIE 11315, Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling, 113151B (16 March 2020); https://doi.org/10.1117/12.2549731

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