Remitted photon path length in human skin, skin phantoms and cell cultures

V. Lukinsone; I. Kuzmina; M. Tamosiunas; A. Maslobojeva; M. Kuzminskis; U. Rubins; J. Spigulis

doi:10.1117/12.2555822

2 April 2020 Remitted photon path length in human skin, skin phantoms and cell cultures

V. Lukinsone, I. Kuzmina, M. Tamosiunas, A. Maslobojeva, M. Kuzminskis, U. Rubins, J. Spigulis

Proceedings Volume 11363, Tissue Optics and Photonics; 1136320 (2020) https://doi.org/10.1117/12.2555822
Event: SPIE Photonics Europe, 2020, Online Only

Abstract

An experimental method for remitted photon path length measurements in scattering media has been developed and tested on human skin and skin neoplasms, skin phantoms and cell cultures. The photon time-of-flight (PTOF) measurement method was used in this study, where the photon travel time was converted into path length. Remitted light signals were obtained using a picosecond broadband laser and a set of narrowband interference filters in spectral rang 520 – 760 nm. Five different distances of 1, 8, 12, 16 and 20 mm between the source and detector fibers were used. Measurements were performed at different wavelengths and distance combinations; they were taken from human skin and skin malformations, agar-based phantoms with different concentrations of intralipid and hemoglobin, and from cell cultures (DC3F, B16/F10). Parameters related to the remitted photon mean path length will be presented and analyzed.

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V. Lukinsone, I. Kuzmina, M. Tamosiunas, A. Maslobojeva, M. Kuzminskis, U. Rubins, and J. Spigulis "Remitted photon path length in human skin, skin phantoms and cell cultures", Proc. SPIE 11363, Tissue Optics and Photonics, 1136320 (2 April 2020); https://doi.org/10.1117/12.2555822

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