Determining morphological structures’ stiffness values of tumor tissue by optical coherence elastography

Anton A. Plekhanov; Marina A. Sirotkina; Vladimir Y. Zaitsev; Ekaterina V. Gubarkova; Sergey S. Kuznetsov; Elena N. Grigoreva; Alexander A. Sovetsky; Lev A. Matveev; Alexander L. Matveyev; Elena V. Zagaynova; Natalia D. Gladkova

doi:10.1117/12.2559476

9 April 2020 Determining morphological structures’ stiffness values of tumor tissue by optical coherence elastography

Anton A. Plekhanov, Marina A. Sirotkina, Vladimir Y. Zaitsev, Ekaterina V. Gubarkova, Sergey S. Kuznetsov, Elena N. Grigoreva, Alexander A. Sovetsky, Lev A. Matveev, Alexander L. Matveyev, Elena V. Zagaynova, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 1145707 (2020) https://doi.org/10.1117/12.2559476
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

As was shown earlier in the animal experiments, compression optical coherence elastography (OCE) is a highly sensitive method for studying the morphological features of biological tissues. An attempt was made to study the possibilities of the OCE method for identifying and differentiating from each other various morphological structures in human tissues. Postoperative samples of human breast cancer and human colon cancer were studied. Histological examination identified areas of morphological structures - (I) adipose tissue, (II) stroma and (III) tumor tissue in breast cancer samples; and areas of (I) mucous membrane and (II) tumor tissue in colon cancer samples. For these areas, an accurate comparison was made with OCE images and stiffness ranges for morphological structures were obtained. This observation allows us to make a conclusion that OСE can be a promising method for studying the structure of human tissue in clinics.

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Anton A. Plekhanov, Marina A. Sirotkina, Vladimir Y. Zaitsev, Ekaterina V. Gubarkova, Sergey S. Kuznetsov, Elena N. Grigoreva, Alexander A. Sovetsky, Lev A. Matveev, Alexander L. Matveyev, Elena V. Zagaynova, and Natalia D. Gladkova "Determining morphological structures’ stiffness values of tumor tissue by optical coherence elastography", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 1145707 (9 April 2020); https://doi.org/10.1117/12.2559476

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