Optical-controlled cryodestruction of biological tissues using sapphire crystals

Arsen Karenovich Zotov; Irina Dolganova; Kirill Zaytsev; Irina Shikunova; Vladimir Kurlov

doi:10.1117/12.2568791

20 August 2020 Optical-controlled cryodestruction of biological tissues using sapphire crystals

Arsen Karenovich Zotov, Irina Dolganova, Kirill Zaytsev, Irina Shikunova, Vladimir Kurlov

Proceedings Volume 11483, Novel Optical Systems, Methods, and Applications XXIII; 114830W (2020) https://doi.org/10.1117/12.2568791
Event: SPIE Optical Engineering + Applications, 2020, Online Only

Conference Poster

Abstract

Cryodestruction is one of the promising medical techniques, which has a lot of advantages. Unfortunately, the monitoring of the ice-ball formation in biological tissue during their freezing is a severe problem. In order to solve it, we suggest applying diffuse reflectance spectroscopy and terahertz spectroscopy for monitoring and implement it by means of a special cryoapplicator, based on sapphire shaped crystals. Sapphire features high transparency in a wide spectral range, chemical resistance, and high thermal conductivity at the cryogenic temperatures, therefore, it is an appropriate material for cryotherapies. Moreover, the technique of growing shaped sapphire enables fabrication of applicators of complex shapes and cross-sections. We demonstrate an example of such applicator of an immersion type with several channels for optical fibers, experimental set-up for study its abilities and experimental results of approbation of such applicator.

Citation Download Citation

Arsen Karenovich Zotov, Irina Dolganova, Kirill Zaytsev, Irina Shikunova, and Vladimir Kurlov "Optical-controlled cryodestruction of biological tissues using sapphire crystals", Proc. SPIE 11483, Novel Optical Systems, Methods, and Applications XXIII, 114830W (20 August 2020); https://doi.org/10.1117/12.2568791

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