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20 August 2020 Selection of hyperosmotic agents for optical clearing of biological tissues in terahertz frequency range
Guzel R. Musina, Nikita V. Chernimyrdin, Arsenii A. Gavdush, Irina N. Dolganova, Valery V. Tuchin, Kirill I. Zaytsev
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Proceedings Volume 11499, Terahertz Emitters, Receivers, and Applications XI; 114990E (2020) https://doi.org/10.1117/12.2567538
Event: SPIE Optical Engineering + Applications, 2020, Online Only
Abstract
Terahertz (THz) spectroscopy and imaging allow to differentiate between healthy tissues and tumors of different types, due to keen sensitivity to the water content. However, a high absorption of THz waves by water molecules limits application of THz technology for medical diagnosis. Among the existing methods for tissue clearing only immersive optical clearing (IOC) is acceptable for in vivo study. In order to choose optimal agents for IOC, we reconstructed THz dielectric properties of common agents using methods of THz pulsed spectroscopy and we measured diffusion coefficients of agents in rat brain analyzing collimated transmittance in visible range.
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Guzel R. Musina, Nikita V. Chernimyrdin, Arsenii A. Gavdush, Irina N. Dolganova, Valery V. Tuchin, and Kirill I. Zaytsev "Selection of hyperosmotic agents for optical clearing of biological tissues in terahertz frequency range", Proc. SPIE 11499, Terahertz Emitters, Receivers, and Applications XI, 114990E (20 August 2020); https://doi.org/10.1117/12.2567538
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KEYWORDS
Tissues
Terahertz radiation
Optical clearing
Biomedical optics
Imaging spectroscopy
Dielectrics
Diffusion
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