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10 October 2020 Recent development in wavefront shaping-enabled optical focusing and its application towards deep-tissue single neuron stimulation
Puxiang Lai, Tianting Zhong
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Proceedings Volume 11551, Holography, Diffractive Optics, and Applications X; 115510S (2020) https://doi.org/10.1117/12.2574028
Event: SPIE/COS Photonics Asia, 2020, Online Only
Abstract
Light is almost ideal to probe and treat biological tissues. Its applications, however, encounter an inevitable trade-off between resolution and penetration depth due to the strong scattering of light in tissue. Existing optical microscopies can seldom see beyond 1 mm beneath human skin. In this talk, we present our endeavors in the past years to achieve high-resolution optical focusing within or through thick biological tissue or tissue-like scattering media via optical wavefront shaping. We also show our preliminary results of applying wavefront shaping implementations towards temporal evolutional optogenetics with single neuron precision through brain skull. Further direction is also discussed.
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Puxiang Lai and Tianting Zhong "Recent development in wavefront shaping-enabled optical focusing and its application towards deep-tissue single neuron stimulation", Proc. SPIE 11551, Holography, Diffractive Optics, and Applications X, 115510S (10 October 2020); https://doi.org/10.1117/12.2574028
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KEYWORDS
Tissue optics
Wavefronts
Neurons
Tissues
Biomedical optics
Light scattering
Diffusion
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